Hi, I was just prescribed Venlafaxine-XR (generic Effexor) today for mild depression, binge eating disorder, generalized anxiety disorder, and social anxiety. I'm suppose to take 37 mg (1/2 of a 75 mg) for the first two weeks and then bump it up to 75 mg and stay on that for a while. What I want to know is, how common is weight gain on this medication?? I'm most worried about that as a lot of my issues revolve around my weight (I get anxious, no motivation, and panicky to leave the house when I gain), I am currently trying to lose some weight that I have gained from recent stress binging and I do not want to gain any extra weight. I also have a low T3 production in my thyroid that I am currently on cytomel for. Oh! I am also on 125mg of Topamax for the binging too...sorry for the rambling I just want to have an idea of the risk of weight gain before I got take my prescription to the pharmacy. Oh and also, does anyone know if there's a significant difference between the generic and brand?? My insurance will only cover the generic...thank you.